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Year : 2013  |  Volume : 40  |  Issue : 1  |  Page : 22-26

Efficacy of botulinum toxin-A versus stabilization occlusal splint in treatment against temporomandibular disorders: a clinical and quantitative electromyographic study

1 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Prosthodontics, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Correspondence Address:
Enas M. Shahine
39 Mostafa Kamel St, Bolkly, 21531 Alexandria
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Source of Support: None, Conflict of Interest: None

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Aim The aim of this study was to evaluate the efficacy of botulinum toxin-A (BTX-A) therapy compared with stabilization occlusal splint in treatment against temporomandibular disorders clinically and by electromyographic quantitative interference pattern analysis (QIPA). Patients and methods Twenty-four female patients with temporomandibular disorder symptoms and signs were enrolled in the study. The patients were randomly assigned into two groups. Patients in group 1 were injected with BTX-A in the affected masseter and temporalis muscles, whereas patients in group 2 were treated with occlusal splint therapy. Patients were evaluated at baseline and at 8 and 12 weeks using the anamnestic dysfunction index, measurement of maximum mouth opening, and surface electromyographic QIPA. Results On follow-up, anamnestic dysfunction index improvement and maximum mouth opening were significantly larger in the BTX-A group than in the splint group. BTX-A injections produced a general reduction in the QIPA parameters of masseter and temporalis muscles at the first follow-up, which increased slightly on the second assessment. In group 2, QIPA parameters were seen to have increased significantly at both assessments. Conclusion BTX-A injection is more advantageous than stabilization splint, provided it is administrated at appropriate doses.

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