• Users Online: 144
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 40  |  Issue : 2  |  Page : 63-69

Electrophysiological study of peripheral nerves in children with acute lymphoblastic leukemia


1 Department of Physical Medicine, Rheumatology and Rehabilitation, Alexandria University, Alexandria, Egypt
2 Department of Pediatric, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Mohamed H. Imam
MD, Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Alexandria University, 574, Horreya Avenue Gleem, apartment 5, Alexandria 02030
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background Estimates of the prevalence of neuropsychiatric manifestations in systemic lupus erythematosis (SLE) range from 14 to over 80% in adults. The clinical manifestations of nervous system involvement in SLE are highly diverse, and their etiology is incompletely understood. Aim of the study The aim of this study was to evaluate the prevalence of neuropsychiatric manifestations in SLE and to correlate the neuropsychiatric damage with the various disease parameters. Patients and methods A total of 100 SLE patients (48 with neuropsychiatric manifestations and 52 without) were subjected to routine laboratory testing and immunological profiling. Systemic Lupus Activity Measure scores were estimated for assessment of disease activity. Assessment of organ damage was carried out according to the Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index. The neuropsychiatric damage was measured with the corresponding domain of the SDI. The cognitive function was assessed, and MRI and electroencephalography were performed when clinically indicated. Results A total of 48% of patients had neuropsychiatric manifestations, of which headache was the most frequent (52%), followed by cognitive deficit (50%), seizures (25%), and cerebrovascular events (25%). On comparing between SLE patients with and without neuropsychiatric manifestations, it was revealed that there was a statistically significant difference between both groups as regards the presence of antiphospholipid (aPL) antibodies (P<0.001), fever, arthritis, and anti-Ro/SSA (P<0.05). The neuropsychiatric damage had a significant positive correlation with the presence of aPL antibodies (r =0.69, Po0.001), presence of anti-Ro/SSA (r = 0.42, Po0.05), disease duration (r =0.38, Po0.05), and disease activity (r = 0.41, P<0.05). Conclusion Neuropsychiatric manifestations in SLE are common; the most prevalent are headache, cognitive deficit, seizures, and cerebrovascular events. Neuropsychiatric damage in SLE patients correlates significantly with the presence of aPL and anti-Ro/SSA antibodies, disease duration, and disease activity.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed374    
    Printed5    
    Emailed0    
    PDF Downloaded64    
    Comments [Add]    

Recommend this journal