• Users Online: 4555
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2013  |  Volume : 40  |  Issue : 2  |  Page : 88-95

Musculoskeletal ultrasonographic assessment of asymptomatic hyperuricemic Egyptian individuals

1 Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Egypt
2 Department of Radiology, Faculty of Medicine, Ain Shams University, Egypt

Correspondence Address:
Takwa B. Younes
MD, Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Ain Shams
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Background Asymptomatic hyperuricemic individuals are discovered accidently on the basis of elevated levels of serum urate. The established use of urate-lowering treatment in patients with gouty arthritis is well documented; however, it is still an issue of research and controversy in individuals with asymptomatic hyperuricemia. Therefore, many attempts have been made to study the influence of asymptomatic hyperuricemia on different musculoskeletal organs. Objectives The aim of this study was to view the ultrasonographic musculoskeletal changes in asymptomatic hyperuricemic individuals and to compare them with the findings in normal controls. Methods Bilateral ultrasonographic examinations of the first metatarsal-phalangeal joints, ankles and knees, as well as of the related tendons and enthesis of the lower limbs, for 40 asymptomatic hyperuricemic individuals and 40 normal controls, were performed. Results A double contour sign was found at the first metatarsal-phalangeal joint in 45% of joints of hyperuricemic individuals but was absent in controls (P<0.001). It was also found in the femoral cartilage in 15% of knees of hyperuricemic individuals but was absent in controls (P<0.0001). Patellar tendenopathy was recorded in 6.25% of tendons. Intratendinous tophi were significantly reported in the patellar and Achilles tendons of patients. Achilles enthesopathy was reported in 18.75% of tendons of patients compared with 2.5% of tendons of controls (P<0.001). Intra-articular tophi were reported in 16 ankle joints (20%) of hyperuricemic individuals but were absent in controls (P<0.001). Conclusion Musculoskeletal ultrasonography of asymptomatic hyperuricemic individuals helps identify morphostructural changes suggestive of gouty arthritis induced by chronic hyperuricemia occurring in both intra-articular and extra-articular structures.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded94    
    Comments [Add]    

Recommend this journal