TY - JOUR A1 - Abo-Elfetoh, Noha A1 - Mohamed, Enass A1 - Tag, Lubna A1 - Gamal, Rania A1 - Gandour, Abeer A1 - Abd EL Razek, Mohamed A1 - El-Baz, Mona A1 - Ez Eldeen, Manal T1 - The relationship between auditory brainstem response, nerve conduction studies, and metabolic risk factors in type II diabetes mellitus Y1 - 2016/10/1 JF - Egyptian Rheumatology and Rehabilitation JO - Egypt Rheumatol Rehabil SP - 163 EP - 171 VL - 43 IS - 4 UR - http://www.err.eg.net/article.asp?issn=1110-161X;year=2016;volume=43;issue=4;spage=163;epage=171;aulast=Abo-Elfetoh DO - 10.4103/1110-161X.192253 N2 - Background Few studies have reported a correlation between auditory brainstem response (ABR) findings and nerve conduction studies (NCSs). The correlation between ABR findings and the metabolic profile of these patients is not well documented in previous studies. The present study was designed to investigate the impact of the disturbed metabolic profile (hyperglyceridemia and hyperlipidemia) in diabetic patients on the peripheral nervous system as well as the auditory brainstem response. Aim The present study aimed to detect the effect of diabetic control on the presence of abnormal ABR and/or peripheral nerve affection in Egyptian diabetic patients. Patients and methods The study was conducted on two groups: the diabetic group (n=68) and the control group, which was matched for age, sex, blood pressure, and BMI (n=60). All participants were subjected to clinical assessment, basic audiologic assessment, brainstem auditory evoked potential, NCS, and metabolic profile [serum level of glycated hemoglobin (HbA1c%) and lipid profile]. Results There was a significant increase in absolute wave latencies of ABR and interpeak latencies (IPLs) in the diabetic group compared with the control group. Twenty-six (38.2%) patients had abnormal ABR values. IPLs (I–III and III–V) were significantly negatively correlated with sensory conduction velocity of the sural, median, and ulnar nerves as well as F-wave latency of the posterior tibial, median, and ulnar nerves (P=0.01 and 0.001, respectively). Moreover, IPL III–V and sural sensory conduction velocity were significantly correlated with HbA1c% and total cholesterol, as well as triglyceride serum levels. Conclusion Brainstem dysfunction and ABR changes are common in patients with type II diabetes mellitus. These changes are significantly correlated to NCS parameters on one hand and serum HbA1c% and lipid profile (total cholesterol and triglycerides) on the other hand. ER -