Egyptian Rheumatology and Rehabilitation

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 40  |  Issue : 4  |  Page : 224--233

Auditory-evoked potentials as a tool for follow-up of fibromyalgia


Ahmed A Abdel-Kader1, Nadia S Kamel1, Amal M El-Ganzouri1, Dina S Al-Zifzaf1, Nadia M Kamal2, Abdel N Omar3 
1 Department of Physical Medicine, Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt
2 Department of Audiology, ENT, Ain Shams University, Cairo, Egypt
3 Department of Neuropsychiatry, Ain Shams University, Cairo, Egypt

Correspondence Address:
Dina S Al-Zifzaf
Associate Professor of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, 11566
Egypt

Aim of the study In this study, we assessed the value of auditory-evoked potentials (AEPs) as objective measurable reproducible tests for the follow-up of patients with fibromyalgia (FM) in response to pharmacologic and rehabilitative therapy. Patients and methods This study included 30 female FM patients and 10 age-matched female controls. All participants underwent a clinical examination, a psychiatric and functional assessment (sleep score, Fibromyalgia Impact Questionnaire, and Hospital Anxiety and Depression Scale) and measurement of AEPs elicited by tones of increasing intensity (60, 70, 80, and 90 dB) known as late cortical responses and cognitive auditory potentials (P300). Patients were subdivided into three equal groups. Group 1 received pregabalin, group 2 received fluoxetine, and group 3 included patients who performed a graded aerobic exercise program. Assessment was repeated at the end of the 8-week treatment period. Results Patients had significantly shorter N1 latencies at 60 and 70 dB, significantly shorter P2 latencies at all the studied intensities, and significantly higher N1P2 amplitudes at 90 dB.There was a statistically significant decrease in amplitude and a significant increase in P300 latency when compared with controls. Changes in AEP values before and after treatment were closely associated with the changes in psychiatric and functional assessment parameters. Conclusion Improvement in the clinical assessment of the different symptoms of FM goes hand in hand with the improvement in the late cortical and cognitive components of AEPs, which provides evidence of the value of AEP as a simple, noninvasive, objective, and reproducible follow-up tool for assessment of hypervigilance and cognitive function in FM patients.


How to cite this article:
Abdel-Kader AA, Kamel NS, El-Ganzouri AM, Al-Zifzaf DS, Kamal NM, Omar AN. Auditory-evoked potentials as a tool for follow-up of fibromyalgia.Egypt Rheumatol Rehabil 2013;40:224-233


How to cite this URL:
Abdel-Kader AA, Kamel NS, El-Ganzouri AM, Al-Zifzaf DS, Kamal NM, Omar AN. Auditory-evoked potentials as a tool for follow-up of fibromyalgia. Egypt Rheumatol Rehabil [serial online] 2013 [cited 2020 Feb 23 ];40:224-233
Available from: http://www.err.eg.net/article.asp?issn=1110-161X;year=2013;volume=40;issue=4;spage=224;epage=233;aulast=Abdel-Kader;type=0