ORIGINAL ARTICLE
Year : 2019 | Volume
: 46 | Issue : 3 | Page : 170--176
Asymptomatic left ventricular diastolic dysfunction in diffuse systemic sclerosis patients: conventional echocardiography and left atrial speckle tracking
Ahmed Aboughanima1, Abdelaziz Gomaa2, Gehan El Olemy3 1 Department of Rheumatology & Rehabilitation, Faculty of Medicine, Benha University, Benha; Department of Internal Medicine, Rheumatology Division, Dallah Hospital, Riyadh, KSA, Egypt 2 Department of Cardiololgy, Faculty of Medicine, Zagazig University, Zagazig; Department of Cardiology, Dallah Hospital, Riyadh, KSA, Egypt 3 Department of Rheumatology & Rehabilitation, Faculty of Medicine, Benha University, Benha; Department of Internal Medicine, Rheumatology Division, Al Adan Hospital, Al Adan, Kuwait
Correspondence Address:
Ahmed Aboughanima Dallah Hospital, Fas, An Nakheel, Riyadh 12381 Egypt
Objective Our objective was to assess asymptomatic left ventricular diastolic dysfunction (LVDD) in diffuse systemic sclerosis (SSc) patients using both conventional and two-dimensional speckle tracking echocardiography in correlation to disease variables.
Patients and methods Twenty-two patients with diffuse SSc without symptoms of LVDD and 22 controls were included in a comparative cross-sectional study. Skin fibrosis was assessed by modified Rodnan skin thickness score and disease severity by Medsger’s score. Parameters related to diastolic functions of the left ventricle were obtained by conventional echocardiography. Assessment of left atrium (LA) functions was by two-dimensional speckle tracking echocardiography as a predictor of LVDD.
Results There were significant differences between patients and controls regarding E-wave deceleration time (194.8±27.3 vs. 157.1±20.3; P<0.001), E/E’ (8.85±1.98 vs. 6.99±0.69; P=0.008), positive peak LAε (11.4±2.9 vs. 18.8±2.28; P<0.001), and sec. positive peak LAε (17.5±3.9 vs. 25.5±2.7; P<0.001). All LA strain parameters were significantly correlated with disease duration, disease severity, N-terminal pro b-type natriuretic peptide, E/E’, and E-wave deceleration time, while positive peak LAε was correlated with the modified Rodnan skin thickness score. Receiver operating characteristic curve analysis identified a positive peak value of less than or equal to 10.8 and sec. positive peak of less than or equal to 17.5 as predictors for the detection of E/E’ more than or equal to 8.
Conclusion LA reservoir and conduit functions were significantly affected in SSc patients than controls and were associated with longer disease duration and more severe disease, while only reservoir function was associated with more fibrotic skin changes. All LA strain parameters correlated significantly with E/E’ ratio, while positive peak LA and sec. positive peak LA were demonstrated as LVDD predictors in patients with diffuse SSc.
How to cite this article:
Aboughanima A, Gomaa A, El Olemy G. Asymptomatic left ventricular diastolic dysfunction in diffuse systemic sclerosis patients: conventional echocardiography and left atrial speckle tracking.Egypt Rheumatol Rehabil 2019;46:170-176
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How to cite this URL:
Aboughanima A, Gomaa A, El Olemy G. Asymptomatic left ventricular diastolic dysfunction in diffuse systemic sclerosis patients: conventional echocardiography and left atrial speckle tracking. Egypt Rheumatol Rehabil [serial online] 2019 [cited 2024 Mar 28 ];46:170-176
Available from: http://www.err.eg.net/article.asp?issn=1110-161X;year=2019;volume=46;issue=3;spage=170;epage=176;aulast=Aboughanima;type=0 |
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